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Gastric Diseases

In 2018, 1 million new cases of gastric cancer were diagnosed1 with a 5 year survival rate of 31%.2 Given these statistics, it is now the 3rd most common cause of cancer related deaths.1

Cellvizio® Clinical Value

Cellvizio® provides physicians with microscopic images of tissue during standard endoscopies, in real-time, which enables a reliable diagnosis of Gastric Intestinal Metaplasia (GIM).3
pCLE combined with targeted conventional endoscopic biopsies allows the detection of Gastric Cancer with an accuracy of 98%.4 Cellvizio’s targeted biopsies also decrease randomized biopsies by 68%.3,4

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“CLE is trustworthy to make on-the-spot decisions on the diagnosis of early gastric cancer, the strategy of endoscopic treatment and follow-up"
Prof. Yanqing Li, Qilu Hospital Shandong University

 

Cellvizio mucosal assessment
using Cellvizio® GastroFlexTM UHD Miniprobe 

Normal Stomach

Criteria: funded glands, regular ranged glands, homogeneous in size and epithelial heights

Gastric Intestinal Metaplasia

Criteria: columnar epithelium with villous appearance, large black goblet cells, vessels with normal calibre

Stomach Cancer

Criteria: atypical/naive glands with dark epithelium, increased calibre and vessels irregular in size and shape

Patient Management

In addition to localizing lesions and targeting biopsies4, physicians with Cellvizio® can detect gastric cancer with an accuracy of 92%,4 as well as evaluate margins before, during and after endoscopic resection.5,6

Gastric Patient management.png

1. World Health Organization: International Agency for Research on cancer, 2018, http://gco.iarc.fr/today/online-analysis-table?v=2018&mode=cancer&mode_population=continents&population=900&populations=900&key=asr&sex=0&cancer=39&type=
1&statistic=5&prevalence=0&population_group=0&ages_group%5B%5D=0&ages_group%5B%5D=17&nb_items=5&group_
cancer=1&include_nmsc=1&include_nmsc_other=1  
2. Harada et al. Recent trend in gastric cancer treatment in the USA, Journal of Cancer Metastasis and Treatment, 2018. 
3. Li Zhen et al. Confocal laser endomicroscopy for in vivo detection of gastric intestinal metaplasia: a randomized controlled trial, Endoscopy, 2013  
4. Bok G.H. et al. The Accuracy of probe-based Confocal Endomicroscopy versus Conventional Endoscopic Biopsies for the Diagnosis of Superficial Neoplasia (with videos). Gastro-Intestinal Endoscopy, 2013. 
5. Ji R, Zuo XL, Li CQ, Zhou CJ, Li YQ. Confocal endomicroscopy for in vivo prediction of completeness after endoscopic mucosal resection. Surg Endosc 2011; 25: 1933-1938
6. Jeon SR, Cho WY, Jin SY, Cheon YK, Choi SR, Cho JY. Optical biopsies by confocal endomicroscopy prevent additive endoscopic biopsies before endoscopic submucosal dissection in gastric epithelial neoplasias: a prospective, comparative study. Gastrointest Endosc 2011; 74: 772-780    

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