Cancer and Disease Development
Molecular imaging of cancer
Longitudinal imaging of pancreatic cancer
Monitor in a minimally invasive manner both tissue morphology and fibrosis (fluorescein) and cathepsin activity (Prosense® 680). A very thin probe (S 650) was used to monitor the pancreas of the same mouse over 9 months.
Tumor neovessels and detection of anti-HER2 nanobody
Tortuous and disorganized neovessels are imaged in a tumor mouse model together with an anti-HER2 nanobody labeled with IRDye680.
In vivo imaging of angiogenesis
Tissue microvasculature and AngioStamp are used to image angiogenesis in a tumor mouse model. AngioStamp binds to αvβ3 integrin which is over-expressed in tumor neovessels.
Monitoring of the immune response during IBD development
The recruitment of GFP-labeled T cells is monitored at different time points in an Inflammatory Bowel Disease mouse model. The cellular-resolution images give information about the heterogeneous distribution of T cells during the development of the disease.
In vivo imaging of fibrosis
Col-F is used to image the extent and localization of elastin and collagen aggregates within a fibrotic mouse kidney.