1 out of 5 pancreatic cysts remains indeterminate after endoscopic ultrasonography1
1 out of 5 pancreatic cysts remains indeterminate after endoscopic ultrasonography (EUS) and over 50% of cysts are missing cytological confirmation after fine-needle aspiration (FNA).1,2 As a result, 40% of patients with benign pancreatic cysts undergo unnecessary surgery due to uncertain diagnoses, and 6 patients out of 10 with pancreatic cysts undergo surgery, of which four are uncertain.3
Cellvizio® Clinical Value
Cellvizio improves characterization of indeterminate cysts, which allows physicians to reduce surgical intervention by 23%.4,5,6,7 As a result, 42% of patients with benign cysts are prevented from further surveillance.8
Needle-based Confocal Laser Endomicroscopy (nCLE) with Cellvizio allows you to see the cyst wall at the microscopic level, in real time, for the first time through a high-speed flexible microscope threaded inside a 19-gauge needle during EUS-FNA procedures.
See one patient case of nCLE in Pancreatic Cyst Assessment with Dr. Bertrand Napoléon, a gastroenterologist and interventional endoscopist.
With Cellvizio, diagnosis is conclusive at 91%.6
The outcomes are positive results that help to completely change patient management by differentiating patients.
Therapeutic decisions have improved by 28%, which eliminates follow ups for some patients.8
Surveillance of serous cystadenomas is eliminated in 42% of cases.8
This allows for a 23% reduction in unnecessary surgeries and a significant economic benefit of a 13% reduction in cost.7
- Dr. C. J. DiMaio, Mount Sinai Hospital
1. Brugge W. et al. Diagnosis of Pancreatic Cystic Neoplasms: A Report of the Cooperative Pancreatic Cyst Study, Gastroenterology, 2004.
2. Van der Waaij. Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis. Gastrointest Endosc. 2005.
3. Jais B. et al. Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas). Gut 2015.
4. Konda VJA, et al. A pilot study of in vivo identification of pancreatic cystic neoplasms with needle-based confocal laser endomicroscoscopy under endosonographic guidance. Endoscopy, 2013. (INSPECT).
5. Nakai Y, et al. Diagnosis of pancreatic cysts: EUS-guided, through-the-needle confocal laser-induced endomicroscopy and cystoscopy trial: DETECT study. Gastrointestinal Endoscopy, 2015.
6. Napoleon B, et al. Needle-based confocal laser endomicroscopy of pancreatic cystic lesions: a prospective multicenter validation study in patients with definite diagnosis, Endoscopy, 2018. (CONTACT 2).
7. Le Pen C et al. A health economic evaluation of needle-based Confocal Laser Endomicroscopy for the diagnosis of pancreatic cysts. Endoscopy International Open (2017).
8. B. Napoleon, needle based confocal laser endomicroscopy: the impact on diagnosis and management of pancreatic cystic lesions, – Presented at DDW 2018.