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This section is intended for Pre-Clinical Use of our System and not for Human Use.

Peripheral nerve imaging

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Use Cellvizio Lab to perform longitudinal studies on the peripheral nervous system.

In vivo imaging of degenerating axons and neuromuscular synapses

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A: A small skin incision is made to expose the tibial nerve and the adjacent gastrocnemius muscle 
B: intramuscular axons and motor nerve terminals in an innervated thy1.2-YFP16 mouse gastrocnemius muscle with an intact sciatic nerve.
C: Axons in the tibial nerve of thy1.2-YFP16 mice all degenerated by 3 days after section of the sciatic nerve, in contrast to the extensive axonal protection seen in WldS mouse nerves.
D: Axotomized tibial nerve axons are also preserved 3 days after sciatic nerve section in thy1.2-YFP16-WldS heterozygotes
E. Intact NMJs in the gastrocnemius muscle of a WldS homozygote were observable 3 days after sciatic nerve injury but, 
F: No intact NMJs were ever seen in thy1.2-YFP/WldS heterozygotes at this time point. 

Article reference: Axonal and neuromuscular synaptic phenotypes in WldS, SOD1G93A and ostes mutant mice identified by fiber-optic confocal microendoscopy. Molecular and Cellular Neuroscience, 10.1016/j.mcn.2009.08.002

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