{"id":8914,"date":"2024-08-05T19:47:48","date_gmt":"2024-08-05T17:47:48","guid":{"rendered":"https:\/\/www.maunakeatech.com\/?page_id=8914"},"modified":"2026-01-28T16:28:00","modified_gmt":"2026-01-28T15:28:00","slug":"lung-nodules","status":"publish","type":"page","link":"https:\/\/www.maunakeatech.com\/int\/indications\/pulmonology\/lung-nodules\/","title":{"rendered":"Lung Nodules"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/www.maunakeatech.com\/wp-content\/uploads\/2024\/06\/AdobeStock_812003556_Preview.jpg&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;80px||100px||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;|&#8211;et_global_heading_font_weight|||||||&#8221; text_text_color=&#8221;#FF6720&#8243; header_font=&#8221;&#8211;et_global_heading_font|&#8211;et_global_heading_font_weight|||||||&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_font_size=&#8221;50px&#8221; header_line_height=&#8221;1.1em&#8221; custom_margin=&#8221;20px||20px||true|false&#8221; header_font_size_tablet=&#8221;50px&#8221; header_font_size_phone=&#8221;45px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1>Lung Nodules<\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;&#8211;et_global_heading_font|300|||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;22px&#8221; text_line_height=&#8221;1.2em&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>Cellvizio<sup>\u00ae<\/sup> is the real-time in vivo cellular imaging platform that enables you to characterize lung nodules with confidence in cases where navigation is difficult or conventional diagnostic screening returns ambiguous results.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(255,255,255,0)&#8221; min_height=&#8221;507.4px&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||70px|||&#8221; custom_padding_tablet=&#8221;||70px|||&#8221; custom_padding_phone=&#8221;||35px||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row make_equal=&#8221;on&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#092840&#8243; custom_padding=&#8221;40px|40px|40px|40px|false|true&#8221; custom_css_main_element=&#8221;min-height:250px;  display: flex;||  flex-direction: column;||  justify-content: center;||||\/* Et les d\u00e9clinaisons avec pr\u00e9fixes pour obtenir un r\u00e9sultat homog\u00e8ne sur les divers navigateurs  *\/||  display: -webkit-box;||  display: -webkit-flex;||  display: -moz-box;||  display: -ms-flexbox;||  -webkit-box-orient: vertical;||  -webkit-box-direction: normal;||  -webkit-flex-direction: column;||     -moz-box-orient: vertical;||     -moz-box-direction: normal;||      -ms-flex-direction: column;||  -webkit-box-pack: center;||  -webkit-justify-content: center;||     -moz-box-pack: center;||      -ms-flex-pack: center;||}&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; border_radii=&#8221;on|20px|20px|20px|20px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;&#8211;et_global_body_font|300|||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;20px&#8221; text_orientation=&#8221;center&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><b><span>Lung cancer is the world\u2019s leading cause of cancer deaths, and its diagnosis remains challenging.<sup>1<\/sup><\/span><\/b><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;20px||||false|false&#8221; custom_margin_tablet=&#8221;20px||||false|false&#8221; custom_margin_phone=&#8221;0px||||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FAFAFA&#8221; text_font_size=&#8221;18px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>While lung cancer starts as small nodules in lung parenchyma commonly, early and accurate diagnosis allows timely surgical resection of malignant nodules while avoiding unnecessary surgery in patients with benign nodules.<br \/>Cellvizio<sup>\u00ae<\/sup> enables you to classify lung nodules in real-time, in vivo, providing you with the advantage of unique visibility and information.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FAFAFA&#8221; text_font_size=&#8221;18px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>The National Lung Screening Trial (NLST) showed that screening high risk patients with low dose chest computed tomogram (CT) reduced mortality from lung cancer by 20%. However, 96% of the positive screens were subsequently found not to be malignant suggesting the need for an accurate diagnostic tool with high specificity.<sup>2<\/sup><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#092840&#8243; z_index=&#8221;0&#8243; custom_padding=&#8221;80px||117px||false|false&#8221; custom_padding_tablet=&#8221;80px||117px||false|false&#8221; custom_padding_phone=&#8221;50px||60px||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_divider color=&#8221;#FF6720&#8243; divider_weight=&#8221;7px&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; width=&#8221;94px&#8221; custom_margin=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_divider][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|&#8211;et_global_heading_font_weight|||||||&#8221; header_2_text_color=&#8221;#FAFAFA&#8221; header_2_font_size=&#8221;40px&#8221; custom_margin=&#8221;||||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2><span><strong><span class=\"blue\">Challenges and Limitations with Current Standards of Care<\/span><\/strong><\/span><\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;2_5,3_5&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;4&#8243; make_equal=&#8221;on&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; custom_padding=&#8221;30px|1px|30px|1px|true|true&#8221; custom_css_main_element=&#8221;align-items:center;&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; border_radii=&#8221;on|30px|30px|30px|30px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/www.maunakeatech.com\/wp-content\/uploads\/2024\/08\/lung-nodules.png&#8221; title_text=&#8221;lung-nodules&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; custom_css_free_form=&#8221;\/* Hide image titles on hover *\/||img {||pointer-events:none;||}&#8221; border_radii=&#8221;on|20px|20px|20px|20px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FAFAFA&#8221; text_font_size=&#8221;18px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>Transthoracic needle aspiration (TTNA) is currently the preferred mode for sampling peripheral pulmonary nodules because it has a high diagnostic yield ranging from 80% to 90%.<sup>3<\/sup>\u00a0However, it has a 12% to 45% risk of pneumothorax with 2% to 15% requiring chest tube placement.<sup>4<\/sup><\/span><\/p>\n<p><span>Flexible bronchoscopy is safer but provides a much lower diagnostic yield (varying from 38.5% to 63.7%) even when using advanced bronchoscope techniques<sup>5<\/sup>, as around 80% of the nodules are located at the periphery of the lung.<sup>6<\/sup>\u00a0This low yield is also a consequence of the lack of positive bronchus sign, as 51.6% of lung nodules do not exhibit a bronchus sign leading directly to the peripheral lung lesion.<sup>7<\/sup>\u00a0The diagnostic yield drops from 79% with a bronchus sign to 31% without it, creating significant challenges.<sup>8<\/sup><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;74px|auto||auto||&#8221; custom_margin_tablet=&#8221;74px|auto||auto||&#8221; custom_margin_phone=&#8221;30px||||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FAFAFA&#8221; text_font_size=&#8221;18px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>Accurate sampling of lung nodules is challenging not only because of their location to the airway but also because of intratumor heterogeneity, even in early cancer.<sup>9<\/sup>\u00a0Despite robotic, advanced navigation, fluoroscopy, cone beam CT, and other technologies, these challenges remain.<\/span><\/p>\n<p><span>As today there is a lack of precise periprocedural intralesional assessment mechanism to not only confirm that FNA is sampling from within the lung nodule, but also to ensure that cell or tissue material retrieved with the needle is from the most abnormal area within the lung nodule.<\/span><\/p>\n<p><span>This combination of issues can lead to late or inaccurate diagnosis with consequences on survival rate, as the sooner the cancer is detected the better it can be treated effectively.<sup>10<\/sup><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#071621&#8243; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_divider color=&#8221;#FF6720&#8243; divider_weight=&#8221;7px&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; width=&#8221;94px&#8221; custom_margin=&#8221;||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_divider][et_pb_text disabled_on=&#8221;on|off|off&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|&#8211;et_global_heading_font_weight|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_text_color=&#8221;#FAFAFA&#8221; header_2_font_size=&#8221;40px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: left;\"><span><b><strong><span class=\"blue\">Introducing Cellvizio<sup>\u00ae<\/sup> needle-based Confocal Laser Endomicroscopy (nCLE)<\/span><\/strong><\/b><\/span><\/h2>\n<p>[\/et_pb_text][et_pb_text disabled_on=&#8221;off|on|on&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|&#8211;et_global_heading_font_weight|||||||&#8221; header_2_text_align=&#8221;center&#8221; header_2_text_color=&#8221;#FAFAFA&#8221; header_2_font_size=&#8221;40px&#8221; header_3_text_color=&#8221;#FAFAFA&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3 style=\"text-align: left;\"><span><b><strong><span class=\"blue\">Introducing Cellvizio<sup>\u00ae<\/sup> needle-based Confocal Laser Endomicroscopy (nCLE)<\/span><\/strong><\/b><\/span><\/h3>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;3_5,2_5&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;4&#8243; make_equal=&#8221;on&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; custom_margin=&#8221;27px|auto||auto||&#8221; custom_padding=&#8221;30px|1px|30px|1px|true|true&#8221; custom_css_main_element=&#8221;align-items:center;&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_video src=&#8221;https:\/\/youtu.be\/cRnnpkdI_qQ&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; border_radii=&#8221;on|20px|20px|20px|20px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_video][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FAFAFA&#8221; text_font_size=&#8221;18px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>Cellvizio<sup>\u00ae<\/sup> is the real-time in vivo cellular imaging platform that can capture images from inside a lung lesion. Deployed through a needle, the nCLE probe enables direct visualization of live cells and their organization from within the lesion, a significant advantage compared to conventional techniques. It will help physicians better target biopsies in the lung.<sup>11<\/sup><\/span><\/p>\n<p><span>Also, by enabling real-time visualization from inside lung nodules and lymph nodes, Cellvizio<sup>\u00ae<\/sup> nCLE may be used as a feedback technique for diagnostic, staging and treatment procedures in lung cancer.<sup>11<\/sup><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_divider color=&#8221;#FFFFFF&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,2_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;4&#8243; make_equal=&#8221;on&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; custom_margin=&#8221;50px|auto||auto||&#8221; custom_padding=&#8221;30px|1px|30px|1px|true|true&#8221; custom_css_main_element=&#8221;align-items:center;&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FAFAFA&#8221; text_font_size=&#8221;18px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>In a recently published study, physicians were also able to accurately discriminate nCLE images and videos of lung tumors from airways and normal lung parenchyma (alveoli).<sup>12<\/sup>\u00a0<\/span><\/p>\n<p><span>More importantly, physicians using Cellvizio<sup>\u00ae<\/sup> nCLE could detect malignancy in tumors and metastatic lymph nodes with an accuracy of up to 95%<sup>11,12,<\/sup>\u00a0leading to better informed patient management.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_video src=&#8221;https:\/\/youtu.be\/nuLWX1SjOEo&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; border_radii=&#8221;on|20px|20px|20px|20px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_video][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FAFAFA&#8221; text_font_size=&#8221;17px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><em><span class=\"blue\">Live from the clinic at ERS 2020, see the clinical utility of Cellvizio<span><sup>\u00ae<\/sup><\/span> in\u00a0<\/span><\/em><br \/><em><span class=\"blue\">characterizing\u00a0<\/span><span class=\"blue\">lung nodules in real time like never before.\u00a0<\/span><\/em><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_divider color=&#8221;#FFFFFF&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.27.5&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243; module_id=&#8221;clinical-value&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text disabled_on=&#8221;on|off|off&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|&#8211;et_global_heading_font_weight|||||||&#8221; header_2_text_color=&#8221;#FF6720&#8243; header_2_font_size=&#8221;40px&#8221; custom_padding=&#8221;||13px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>Cellvizio<span><sup>\u00ae <\/sup><\/span><span>Clinical Value<\/span><\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=&#8221;off|on|on&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_divider color=&#8221;#FFFFFF&#8221; disabled_on=&#8221;off|on|on&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text disabled_on=&#8221;off|on|on&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|&#8211;et_global_heading_font_weight|||||||&#8221; header_2_text_color=&#8221;#FF6720&#8243; header_2_font_size=&#8221;40px&#8221; header_3_text_color=&#8221;#FF6720&#8243; custom_padding=&#8221;||13px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Cellvizio<span><sup>\u00ae <\/sup><\/span><span>Clinical Value<\/span><\/h3>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;3_5,2_5&#8243; disabled_on=&#8221;on|off|off&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_video src=&#8221;https:\/\/www.maunakeatech.com\/wp-content\/uploads\/2025\/02\/EN-Renaud-Cellvizio-Interview-2.mp4&#8243; image_src=&#8221;https:\/\/www.maunakeatech.com\/wp-content\/uploads\/2024\/09\/Dr_Jason_Samarasena_-_Social_Media_Video-1.png&#8221; play_icon_color=&#8221;#071621&#8243; font_icon=&#8221;&#xf144;||fa||900&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;|-58px||||&#8221; custom_padding=&#8221;|28px||||&#8221; border_radii=&#8221;on|35px|35px|35px|35px&#8221; global_colors_info=&#8221;{}&#8221; play_icon_color__hover_enabled=&#8221;on|hover&#8221; play_icon_color__hover=&#8221;#FFFFFF&#8221;][\/et_pb_video][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;18px&#8221; background_color=&#8221;#fafafa&#8221; text_orientation=&#8221;center&#8221; custom_margin=&#8221;-2rem||0px|-35px|false|false&#8221; custom_padding=&#8221;124px|50px|30px|50px|false|true&#8221; border_radii=&#8221;off|30px|30px||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Watch the interview with Professor St\u00e9phane Renaud from Nancy University Hospital, who discusses improving diagnostic yield, saving time in the biopsy procedure, and optimizing patient care by reducing access time to treatment\/surgery.<\/p>\n<p>[\/et_pb_text][et_pb_blurb icon_alignment=&#8221;left&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; header_level=&#8221;h6&#8243; header_font=&#8221;&#8211;et_global_heading_font|&#8211;et_global_heading_font_weight|||||||&#8221; header_text_align=&#8221;center&#8221; header_text_color=&#8221;#41B6E6&#8243; background_color=&#8221;#fafafa&#8221; custom_margin=&#8221;|||-35px||&#8221; custom_padding=&#8221;|48px|60px|48px|false|true&#8221; custom_css_blurb_image=&#8221;float:left;||margin-right:20px;&#8221; border_radii=&#8221;off|||30px|30px&#8221; border_radii_image=&#8221;on|30px|30px|30px|30px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=&#8221;off|on|on&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px|||||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_video src=&#8221;https:\/\/www.maunakeatech.com\/wp-content\/uploads\/2025\/02\/EN-Renaud-Cellvizio-Interview-2.mp4&#8243; image_src=&#8221;https:\/\/www.maunakeatech.com\/wp-content\/uploads\/2024\/09\/Dr_Jason_Samarasena_-_Social_Media_Video-1.png&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; border_radii=&#8221;on|35px|35px|35px|35px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_video][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=&#8221;off|on|on&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_testimonial quote_icon=&#8221;off&#8221; disabled_on=&#8221;off|on|on&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; author_text_color=&#8221;#41B6E6&#8243; border_radii=&#8221;on|30px|30px|30px|30px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Watch the interview with Professor St\u00e9phane Renaud from Nancy University Hospital, who discusses improving diagnostic yield, saving time in the biopsy procedure, and optimizing patient care by reducing access time to treatment\/surgery.<\/p>\n<p>[\/et_pb_testimonial][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; make_equal=&#8221;on&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;60px|auto||auto||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#092840&#8243; custom_padding=&#8221;40px|40px|40px|40px|false|true&#8221; custom_css_main_element=&#8221;min-height:250px;  display: flex;||  flex-direction: column;||  justify-content: center;||||\/* Et les d\u00e9clinaisons avec pr\u00e9fixes pour obtenir un r\u00e9sultat homog\u00e8ne sur les divers navigateurs  *\/||  display: -webkit-box;||  display: -webkit-flex;||  display: -moz-box;||  display: -ms-flexbox;||  -webkit-box-orient: vertical;||  -webkit-box-direction: normal;||  -webkit-flex-direction: column;||     -moz-box-orient: vertical;||     -moz-box-direction: normal;||      -ms-flex-direction: column;||  -webkit-box-pack: center;||  -webkit-justify-content: center;||     -moz-box-pack: center;||      -ms-flex-pack: center;||}&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; border_radii=&#8221;on|20px|20px|20px|20px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;&#8211;et_global_body_font|300|||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;18px&#8221; text_orientation=&#8221;center&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong><span class=\"blue\">News about Cellvizio<span><sup>\u00ae<\/sup><\/span> nCLE<br \/><\/span><\/strong><br \/><span>Mauna Kea Technologies Announces the Launch of a First in Human Study Combining Robotic Navigational Bronchoscopy and Needle-Based Confocal Laser Endomicroscopy (Clinicaltrials.gov: NCT04441749)<\/span><\/p>\n<p><strong><a href=\"https:\/\/www.maunakeatech.com\/int\/news-int\/mauna-kea-technologies-announces-the-launch-of-a-first-in-human-study-combining-robotic-navigational-bronchoscopy-and-needle-based-confocal-laser-endomicroscopy-2\/\">See press release<\/a><\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#071621&#8243; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;0px||||false|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_divider color=&#8221;#FF6720&#8243; divider_weight=&#8221;7px&#8221; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; width=&#8221;94px&#8221; module_alignment=&#8221;left&#8221; custom_margin=&#8221;||0px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_divider][et_pb_text disabled_on=&#8221;on|off|off&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|&#8211;et_global_heading_font_weight|||||||&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FAFAFA&#8221; header_2_font_size=&#8221;40px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2><span><b><strong><span class=\"blue\">Lung Lesion Characterization Using Cellvizio<sup>\u00ae<\/sup> nCLE (AQ-Flex\u2122 19) Miniprobe<\/span><\/strong><\/b><\/span><\/h2>\n<p>[\/et_pb_text][et_pb_text disabled_on=&#8221;off|on|on&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|&#8211;et_global_heading_font_weight|||||||&#8221; header_2_text_align=&#8221;left&#8221; header_2_text_color=&#8221;#FAFAFA&#8221; header_2_font_size=&#8221;40px&#8221; header_3_text_color=&#8221;#FAFAFA&#8221; header_4_text_color=&#8221;#FAFAFA&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4><span><b><strong><span class=\"blue\">Lung Lesion <\/span><\/strong><\/b><\/span><span><b><strong><span class=\"blue\">Characterization <\/span><\/strong><\/b><\/span><\/h4>\n<h4><span><b><strong><span class=\"blue\">Using <\/span><\/strong><\/b><\/span><span><b><strong><span class=\"blue\">Cellvizio<sup>\u00ae<\/sup> nCLE <\/span><\/strong><\/b><\/span><\/h4>\n<h4><span><b><strong><span class=\"blue\">(AQ-Flex\u2122 19) Miniprobe<\/span><\/strong><\/b><\/span><\/h4>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#092840&#8243; width_tablet=&#8221;&#8221; width_phone=&#8221;90%&#8221; width_last_edited=&#8221;on|phone&#8221; max_width=&#8221;1200px&#8221; custom_margin=&#8221;40px||||false|false&#8221; custom_padding=&#8221;50px|70px|50px|70px|true|true&#8221; custom_padding_tablet=&#8221;50px|70px|50px|70px|true|true&#8221; custom_padding_phone=&#8221;50px|30px|50px|30px|true|true&#8221; border_radii=&#8221;on|20px|20px|20px|20px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;&#8211;et_global_heading_font|&#8211;et_global_heading_font_weight|||||||&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_3_font=&#8221;&#8211;et_global_heading_font|&#8211;et_global_heading_font_weight|||||||&#8221; header_3_text_align=&#8221;center&#8221; header_3_text_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;||15px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Airways criteria*<\/h3>\n<p>[\/et_pb_text][et_pb_divider color=&#8221;#FF6720&#8243; divider_weight=&#8221;4px&#8221; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; width=&#8221;60px&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_css_main_element=&#8221;margin-left: auto;||margin-right: auto;&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_divider][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FAFAFA&#8221; text_orientation=&#8221;center&#8221; min_height=&#8221;30px&#8221; min_height_tablet=&#8221;30px&#8221; min_height_phone=&#8221;30px&#8221; min_height_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;||0px|||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li style=\"text-align: left;\"><span>Absence of directional streaming<\/span><\/li>\n<li style=\"text-align: left;\"><span>Elastin deposits<\/span><\/li>\n<li style=\"text-align: left;\"><span>Homogenous enlarged cells in an equal distance<\/span><\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/www.maunakeatech.com\/wp-content\/uploads\/2024\/08\/airways-criteria.png&#8221; title_text=&#8221;airways-criteria&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; custom_margin_tablet=&#8221;&#8221; custom_margin_phone=&#8221;||30px||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; border_radii=&#8221;on|20px|20px|20px|20px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;&#8211;et_global_heading_font|&#8211;et_global_heading_font_weight|||||||&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_3_font=&#8221;&#8211;et_global_heading_font|&#8211;et_global_heading_font_weight|||||||&#8221; header_3_text_align=&#8221;center&#8221; header_3_text_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;||15px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Alveoli*<\/h3>\n<p>[\/et_pb_text][et_pb_divider color=&#8221;#FF6720&#8243; divider_weight=&#8221;4px&#8221; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; width=&#8221;60px&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_css_main_element=&#8221;margin-left: auto;||margin-right: auto;&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_divider][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FAFAFA&#8221; text_orientation=&#8221;center&#8221; min_height=&#8221;85px&#8221; min_height_tablet=&#8221;85px&#8221; min_height_phone=&#8221;85px&#8221; min_height_last_edited=&#8221;on|phone&#8221; custom_margin_tablet=&#8221;&#8221; custom_margin_phone=&#8221;||0px||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>Alveolar tissue<\/span><\/p>\n<p>[\/et_pb_text][et_pb_video src=&#8221;https:\/\/cdn2.maunakeatech.com\/\/uploads\/media\/media_video\/0001\/03\/Alveoli.mp4&#8243; image_src=&#8221;https:\/\/www.maunakeatech.com\/wp-content\/uploads\/2024\/08\/alveoli.png&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;117px||||false|false&#8221; custom_margin_tablet=&#8221;50px||||false|false&#8221; custom_margin_phone=&#8221;0px||30px||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; border_radii=&#8221;on|20px|20px|20px|20px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_video][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; header_font=&#8221;&#8211;et_global_heading_font|&#8211;et_global_heading_font_weight|||||||&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_3_font=&#8221;&#8211;et_global_heading_font|&#8211;et_global_heading_font_weight|||||||&#8221; header_3_text_align=&#8221;center&#8221; header_3_text_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;||15px||false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Necrosis*<\/h3>\n<p>[\/et_pb_text][et_pb_divider color=&#8221;#FF6720&#8243; divider_weight=&#8221;4px&#8221; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; background_enable_color=&#8221;off&#8221; width=&#8221;60px&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_css_main_element=&#8221;margin-left: auto;||margin-right: auto;&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_divider][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FAFAFA&#8221; text_orientation=&#8221;center&#8221; min_height=&#8221;85px&#8221; min_height_tablet=&#8221;85px&#8221; min_height_phone=&#8221;85px&#8221; min_height_last_edited=&#8221;on|phone&#8221; custom_margin_tablet=&#8221;&#8221; custom_margin_phone=&#8221;||0px||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; custom_padding=&#8221;||0px|||&#8221; custom_padding_tablet=&#8221;||0px|||&#8221; custom_padding_phone=&#8221;||0px||false|false&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>Loss of contact signal<\/span><\/p>\n<p>[\/et_pb_text][et_pb_video src=&#8221;https:\/\/cdn2.maunakeatech.com\/\/uploads\/media\/media_video\/0001\/03\/Necrosis.mp4&#8243; image_src=&#8221;https:\/\/www.maunakeatech.com\/wp-content\/uploads\/2024\/08\/necrosis.png&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;113px||||false|false&#8221; custom_margin_tablet=&#8221;50px||||false|false&#8221; custom_margin_phone=&#8221;0px||||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221; border_radii=&#8221;on|20px|20px|20px|20px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_video][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;74px|auto||auto||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text disabled_on=&#8221;on|off|off&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FAFAFA&#8221; text_font_size=&#8221;18px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>For professional investors only:\u00a0goetzpartners securities Limited issued a report which highlights how interventional pulmonology represents a promising commercial opportunity for Cellvizio<\/span><sup>\u00ae<\/sup><span>, and is available<a href=\"https:\/\/www.maunakeatech.com\/wp-content\/uploads\/2025\/06\/goetzpartners_10102019_MKEA.pdf\" target=\"_blank\" rel=\"noopener\">\u00a0<\/a><\/span><a href=\"https:\/\/www.maunakeatech.com\/wp-content\/uploads\/2025\/06\/goetzpartners_10102019_MKEA.pdf\" target=\"_blank\" rel=\"noopener\">for download here<\/a><span>.<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text disabled_on=&#8221;off|on|on&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FAFAFA&#8221; text_font_size=&#8221;18px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>For professional investors only:\u00a0<\/span><\/p>\n<p><span>goetzpartners securities Limited issued a report which highlights how interventional pulmonology represents a promising commercial opportunity for Cellvizio<\/span><sup>\u00ae<\/sup><span>, and is available<a href=\"https:\/\/www.maunakeatech.com\/wp-content\/uploads\/2025\/06\/goetzpartners_10102019_MKEA.pdf\">\u00a0<\/a><\/span><a href=\"https:\/\/www.maunakeatech.com\/wp-content\/uploads\/2025\/06\/goetzpartners_10102019_MKEA.pdf\">for download here<\/a><span>.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#092840&#8243; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;30px||30px||true|false&#8221; da_disable_devices=&#8221;off|off|off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_toggle title=&#8221;References &#038; disclaimers&#8221; open_toggle_text_color=&#8221;#FFFFFF&#8221; open_toggle_background_color=&#8221;#071621&#8243; closed_toggle_text_color=&#8221;#FFFFFF&#8221; closed_toggle_background_color=&#8221;#071621&#8243; icon_color=&#8221;#FFFFFF&#8221; toggle_icon=&#8221;&#x33;||divi||400&#8243; use_icon_font_size=&#8221;on&#8221; icon_font_size=&#8221;36px&#8221; open_icon_color=&#8221;#FFFFFF&#8221; open_toggle_icon=&#8221;&#x32;||divi||400&#8243; open_use_icon_font_size=&#8221;on&#8221; open_icon_font_size=&#8221;36px&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; title_font=&#8221;|700|||||||&#8221; title_font_size=&#8221;18px&#8221; closed_title_font=&#8221;|600|||||||&#8221; body_text_color=&#8221;#FFFFFF&#8221; body_font_size=&#8221;14px&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;30px|40px|30px|40px|true|true&#8221; custom_css_free_form=&#8221;selector .et_pb_toggle_content li {||  padding-bottom:8px;||}||selector .et_pb_toggle_content li:marker {||  font-weight:700;||}&#8221; border_radii=&#8221;on|15px|15px|15px|15px&#8221; border_width_all=&#8221;0px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><span>* Images and videos courtesy of Pr. Annema and Dr. Wijmans, Department of Pulmonology, Amsterdam University Medical Center<\/span><\/p>\n<p><span>1. GLOBOCAN 2018, Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68(6):394\u2013424. https:\/\/doi.org\/10.3322\/caac.21492 PMID:30207593<br \/>2. The NLST Research Team. Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening. N Engl J Med. 2011 Aug;365(5):395\u2013409.<br \/>3. Hiraki T, Mimura H, Gobara H, Shibamoto K, Inoue D, Matsui Y, et al. Incidence of and Risk Factors for Pneumothorax and Chest Tube Placement After CT Fluoroscopy\u2013Guided Percutaneous Lung Biopsy: Retrospective Analysis of the Procedures Conducted Over a 9-Year Period. Am J Roentgenol. 2010 Mar; 194(3):809\u201314.<br \/>4. Gupta S, Wallace MJ, Cardella JF, Kundu S, Miller DL, Rose SC, et al. Quality improvement guidelines for percutaneous needle biopsy. J Vasc Interv Radiol JVIR. 2010 Jul;21(7):969\u201375.<br \/>5. Ost D.E. et al. Diagnostic Yield and Complications of Bronchoscopy for Peripheral Lung Lesions. Results of the AQuIRE Registry. Am J Respir Crit Care Med, 2017.<br \/>6. Heuvelmans, A. Et al. Relationship between nodule count and lung cancer probability in baseline CT lung cancer screening: The NELSON study. Lung Cancer, 2017.<br \/>7. Sandeep J. Khandhar, Mark R. Bowling, Javier Flandes, et. al.; Electromagnetic navigation bronchoscopy to access lung lesions in 1,000 subjects: first results of the prospective, mulitcenter NAVIGATE Study<br \/>8. Seijo LM, de Torres JP, Lozano MD , et al. Diagnostic yield of electromagnetic navigation bronchoscopy is highly dependent on the presence of a Bronchus sign on CT imaging: results from a prospective study. Chest 2010; 138 (6) 1316-1321<br \/>9. Senosain MF, Massion PP. Intratumor Heterogeneity in Early Lung Adenocarcinoma. Front Oncol. 2020;10:349. Published 2020 Mar 17. doi:10.3389\/fonc.2020.00349<br \/>10. Cancer Stat Facts: Lung and Bronchus Cancer.&#8221; National Cancer Institute, https:\/\/seer.cancer.gov\/ statfacts\/html\/lungb.html<br \/>11. Wijmans L. et al. Needle-based confocal laser endomicroscopy (nCLE) for real-time diagnosing and staging of lung cancer, European Respiratory Journal, 2019.<br \/>12. Kramer T, Wijmans L, de Bruin DM, Bonta PI, Annema JT. Bronchoscopic needle based Confocal Laser Endomicroscopy (nCLE) as a real-time detection tool for peripheral lung cancer. Department of Pulmonology, Amsterdam University Medical Center. ERS Presentation 2020.<\/span><\/p>\n<p><span>Cellvizio<sup>\u00ae<\/sup>\u00a0I.V.E. with Confocal Miniprobes<\/span><span><sup>TM<\/sup><\/span><span>\u00a0are regulated Medical Devices, CE marked (CE 0459) (Class IIa &#8211; NB : G-MED) and FDA cleared. Cellvizio<sup>\u00ae<\/sup>\u00a0is a registered trademark and Confocal Miniprobe<\/span><span><sup>TM<\/sup><\/span><span>\u00a0is a trademark of Mauna Kea Technologies. Cellvizio<sup>\u00ae<\/sup>\u00a0I.V.E. with Confocal Miniprobes<\/span><span><sup>TM<\/sup><\/span><span>\u00a0is a confocal laser system with fiber optic probes that are intended to allow imaging of the internal microstructure of tissues including, but not limited to, the identification of cells and vessels and their organization or architecture. FDA clearance: indications for use: Once connected to the Cellvizio<sup>\u00ae<\/sup>\u00a0I.V.E: The AQ-Flex<\/span><span><sup>TM<\/sup><\/span><span>\u00a019 Confocal Miniprobes<\/span><span><sup>TM<\/sup><\/span><span>\u00a0are intended to allow imaging of anatomical tracts, i.e., gastrointestinal and respiratory tracts, accessed by an endoscope, or endoscopic accessories (e.g. aspiration needles used during procedures including EUS-FNA, EBUS-TBNA and TBNA needles). CE marked: indications for use: Once connected to the Cellvizio<sup>\u00ae<\/sup>\u00a0I.V.E: The AQ-Flex<\/span><span><sup>TM<\/sup><\/span><span>\u00a019 Confocal Miniprobes<\/span><span><sup>TM<\/sup><\/span><span>\u00a0are intended to allow imaging of anatomical tracts, i.e., gastrointestinal tracts and respiratory tracts accessed by an endoscope or endoscopic accessories, including through endoscopic needles. Please consult labels and instructions for use. These statements and the associated reference to specific clinical studies, are not intended to represent claims of safety or effectiveness for detecting or treating any specific condition or disease state. Rather this information is intended to provide useful reference to selected published literature describing physician experiences with the associated clinical uses. Any diagnostic assessment should always be made by the attending physician, based on the evaluation of all sources of clinical, endoscopic and other relevant information. These statements have not been reviewed, cleared, or approved by the U.S. FDA. The use of this medical device is exclusively reserved for health professionals. Product availability cannot be guaranteed in all countries. For further information, please contact your local sales<br \/>representative.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_toggle][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;news-events&#8221; module_id=&#8221;news-events&#8221; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(255,255,255,0)&#8221; da_disable_devices=&#8221;off|off|off&#8221; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221; da_is_popup=&#8221;off&#8221; da_exit_intent=&#8221;off&#8221; da_has_close=&#8221;on&#8221; da_alt_close=&#8221;off&#8221; da_dark_close=&#8221;off&#8221; da_not_modal=&#8221;on&#8221; da_is_singular=&#8221;off&#8221; da_with_loader=&#8221;off&#8221; da_has_shadow=&#8221;on&#8221;][et_pb_row custom_padding_last_edited=&#8221;on|phone&#8221; _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; custom_padding_tablet=&#8221;&#8221; custom_padding_phone=&#8221;||0px||false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.25.0&#8243; _module_preset=&#8221;default&#8221; pac_dcm_carousel_specific_module_num=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;|700|||||||&#8221; text_text_color=&#8221;#41B6E6&#8243; text_font_size=&#8221;22px&#8221; custom_margin=&#8221;||20px||false|false&#8221; custom_padding=&#8221;||22px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>News\u00a0<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.27.0&#8243; _module_preset=&#8221;default&#8221; header_2_font=&#8221;|&#8211;et_global_heading_font_weight|||||||&#8221; header_2_text_color=&#8221;#FAFAFA&#8221; header_2_font_size=&#8221;40px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 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conventional diagnostic screening returns ambiguous results.Lung cancer is the world\u2019s leading cause of cancer deaths, and its diagnosis remains challenging.1While lung cancer starts as small nodules in lung parenchyma [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":0,"parent":32,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<!-- wp:divi\/placeholder \/-->","_et_gb_content_width":"","footnotes":""},"class_list":["post-8914","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lung Nodules - Mauna Kea Technologies<\/title>\n<meta name=\"description\" content=\"Cellvizio\u00ae is the real-time in vivo cellular imaging platform that enables you to characterize lung nodules with confidence in cases where navigation is difficult or conventional 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