Drug discovery and development
In the field of drug discovery and development, Cellvizio technology is mainly used to:
- Evaluate new drug delivery tools to cross the blood-brain barrier or to access very specific tumor sites
- Monitor in real time the delivery of a drug candidate to a target site
- Follow the effect of a drug on tissue vasculature or histology
Real-time follow-up of nanoparticles aggregation in tumor microcirculation for targeted drug delivery
In this example, the aggregation of magnetic nanoparticles labeled with DiR is monitored in real time. Tumor microvasculature is labeled using FITC-Dextran.
Control experiment: non-magnetic nanoparticles do not aggregate during the application of a magnetic field.
Magnetic nanoparticles aggregate during the application of a magnetic field. They aggregate near the tumor vessel wall. No vascular damage is observed.
Videos courtesy of K. T. Al-Jamal, Drug delivery group, Institute of Pharmaceutical Sciences, King's College London, UK.
Article reference: Real-time monitoring of magnetic drug targeting using fibered confocal fluorescence microscopy. Journal of Controlled Release, 10.1016/j.jconrel.2016.07.026
Effect drug treatment on tissue vasculature
This video confirms the integrity of the blood-brain barrier after epilepsy treatment.