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This section is intended for Pre-Clinical Use of our System and not for Human Use.

Cancer and Disease Development

Molecular imaging of cancer

Longitudinal imaging of pancreatic cancer

Monitor in a minimally invasive manner both tissue morphology and fibrosis (fluorescein) and cathepsin activity (Prosense® 680). A very thin probe (S 650) was used to monitor the pancreas of the same mouse over 9 months.

Tumor neovessels and detection of anti-HER2 nanobody

Tortuous and disorganized neovessels are imaged in a tumor mouse model together with an anti-HER2 nanobody labeled with IRDye680. 

In vivo imaging of angiogenesis

Tissue microvasculature and AngioStamp are used to image angiogenesis in a tumor mouse model. AngioStamp binds to αvβ3 integrin which is over-expressed in tumor neovessels.

Monitoring of the immune response during IBD development

The recruitment of GFP-labeled T cells is monitored at different time points in an Inflammatory Bowel Disease mouse model. The cellular-resolution images give information about the heterogeneous distribution of T cells during the development of the disease.

In vivo imaging of fibrosis

Col-F is used to image the extent and localization of elastin and collagen aggregates within a fibrotic mouse kidney.

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