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Interventional Pulmonology

Lung cancer is the world’s leading cause of cancer deaths, and is largely preventable

Lung cancer is responsible for 1 in 5 cancer deaths and largely preventable.1,2 Biopsy diagnostic yield using current standards of care varies from 46% to 88% in advanced bronchoscope techniques, and complications due to lung biopsies are associated with morbidity risk.3,4

Mauna Kea Technologies has been working on innovative solutions to help interventional pulmonologists achieve early diagnoses for many years. Lately, these solutions have shown great promises for the improvement of lung cancer diagnosis, as published by leading academic and clinician teams around the world.5,6,7,8

Cellvizio® complements existing and novel solutions for bronchoscopy examinations, such as navigation techniques and platforms, and endoluminal robotics systems. 

Cellvizio® needle-based Confocal Laser Endomicroscopy (nCLE) solutions for interventional pulmonology applications

Cellvizio® needle-based Confocal Laser Endomicroscopy (nCLE) has been used for many years with great success for the visualization of Pancreatic Cystic Lesions.9,10 Used through a 19-gauge needle, nCLE offers unique microscopic views of the inner wall of pancreatic cysts, enabling physicians to characterize these important lesions with much higher accuracy.9,10

Over the past few years, the team of Prof. dr. Jouke Annema, at the University Medical Center in Amsterdam, has used Cellvizio® nCLE solutions to image inside pulmonary lesions, through a 19-gauge needle, passed through the working channel of a bronchoscope.

While navigation systems may position the bronchoscope in the vicinity of the peripheral nodule, because the nodule is outside the airways in 80% of cases11, the operator cannot directly visualize the nodule with the bronchoscope and needs to use a needle to go through the airways.

The use of Cellvizio® nCLE may help physicians better target biopsies in the lung5-7, and enables real-time visualization and staging from inside lung nodules and lymph nodes.8

Cellvizio® captures in vivo images in real-time, providing clinical information, and may provide in situ guidance for targeted biopsy. The result is the ability to characterize lung lesions, differentiating benign vs. malignant.5-8 In a recently published study, physicians using Cellvizio® could diagnose and stage lung nodules with 90% accuracy8, leading to better informed patient management.

For professional investors only: goetzpartners securities Limited issued a report which highlights how interventional pulmonology represents a promising commercial opportunity for Cellvizio®, and is available for download here.

1. The American Cancer Society medical and editorial content team, Key statistics for Lung Cancer, 2019.
2. Lung Cancer, American Cancer Society, http://canceratlas.cancer.org/the-burden/lung-cancer/, Accessed May 31 2019.
3. Ost D.E. et al. Diagnostic Yield and Complications of Bronchoscopy for Peripheral Lung Lesions. Results of the AQuIRE Registry. Am J Respir Crit Care Med, 2017.
4. Carol C. Wu. et al. Complications of CT-Guided Percutaneous Needle Biopsy of the Chest: Prevention and Management, American Journal of Roentgenology, 2011.
5. Fuchs F.S. et al. Confocal Laser Endomicroscopy for diagnosing Lung Cancer in vivo. European Respiratory Journal, 2013.
6. Sorokina A. et al. Comparative study of ex vivo probe-based confocal laser endomicroscopy and light microscopy in lung cancer diagnostics. Respirology, 2014.
7. Wellikoff A. et al. Comparison of in vivo probe-based confocal laser endomicroscopy with histopathology in lung cancer: A move toward optical biopsy. Respirology, 2015.
8. Wijmans L. et al. Needle-based confocal laser endomicroscopy (nCLE) for real-time diagnosing and staging of lung cancer, European Respiratory Journal, 2019.
9. Napoléon B, et al. Needle-based confocal laser endomicroscopy of pancreatic cystic lesions: a prospective multicenter validation study in patients with definite diagnosis, Endoscopy, 2018. (CONTACT 2).

10. Krishna SG, et al. Endoscopic Ultrasound-Guided Confocal Laser Endomicroscopy Increases Accuracy of Differentiation of Pancreatic Cystic Lesions, Clinical Gastroenterology and Hepatology, 2019.
11. Heuvelmans, A. Et al. Relationship between nodule count and lung cancer probability in baseline CT lung cancer screening: The NELSON study. Lung Cancer, 2017.

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Cellvizio Brochure