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Colorectal Lesions

Cellvizio aids in the management of colorectal neoplasia for the real time polyp characterization and treatment follow up

Optical Biopsy with Cellvizio enables physicians to view tissue at the cellular level during standard endoscopies, which helps differentiate between non-neoplastic and neoplastic tissue . This technique allows for a real time characterization of polyps during screening colonoscopies and identification of lesions at risk for cancer. 

With the help of endomicroscopy, physicians can also better detect residual neoplasia following EMR as compared with WLE, and adapt the re-treatment modalities if needed. 1,2,3,4,6 

Cellvizio Optical Biopsy is a through-the-scope procedure that fits any standard practice and equipment.

Healthy Colon

Visualized with Cellvizio ColoFlex UHD miniprobe

Colon Adenocarcinoma

Visualized with Cellvizio ColoFlex UHD miniprobe

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The addition of pCLE provides higher sensitivity and excellent NPV, thus allowing a highly accurate decision to not treat again in cases where lesions appear to be non-neoplastic.

Muhammad W. Shahid, MD

Mayo Clinic, Jacksonville, FL, USA2

  1. Ussui V.M. et al. Confocal Endomicroscopy of Colorectal Polyps. Gastroenterology Research and Practice, 2012.
  2. Buchner A.M. et al. Comparison of Probe-Based Confocal Laser Endomicroscopy With Virtual Chromoendoscopy for Classification of Colon Polyps. Gastroenterology, 2010.
  3. Shahid M.W. et al. Diagnostic Accuracy of Probe-Based Confocal Laser Endomicroscopy and Narrow Band Imaging for Small Colorectal Polyps: A Feasibility Study. American Journal of Gastroenterology , 2012.
  4. Gómez V. et al. Interobserver Agreement and Accuracy among International Experts with probe-based Confocal Laser Endomicroscopy in Predicting Colorectal Neoplasia . Endoscopy, 2010.
  5. Buchner A.M. et al. The Learning Curve of in vivo probe-based Confocal Laser Endomicroscopy for Prediction of Colorectal Neoplasia. Gastrointestinal Endoscopy, 2011.
  6. Shahid M.W. et al. Diagnostic Accuracy of probe based Confocal Laser Endomicroscopy in Detecting Residual Colorectal Neoplasia after EMR: A prospective Study. Gastrointestinal Endoscopy, 2012.
  7. Shahid M.W. et al. Accuracy of Real-time vs. Blinded Offline Diagnosis of Neoplastic Colorectal Polyps using probe-based Confocal Laser Endomicroscopy: a Pilot Study. Endoscopy, 2012.

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